CAMP catabolic process

Across TCGA patient cohorts, RNA activity of the CAMP catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CFH, CD248_S746, and ERBB3_S686, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, CAMP catabolic process activity versus CFH in OV (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CFH →	+0.637	+0.036	.002	.007	3	7
LUAD	CD248_S746 →	+0.402	+0.071	<.001	<.001	3	6
OV	ERBB3_S686 →	-1.054	-0.043	.003	.003	3	6
LUAD	LAMB1 →	+0.311	+0.070	<.001	<.001	3	6
LUAD	NNMT →	+0.466	+0.070	<.001	<.001	3	6
LUAD	PDE4D →	+0.687	+0.086	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006198 vs CFH — OV

Explore this scatter interactively →