CAMP catabolic process

Across TCGA patient cohorts, RNA activity of the CAMP catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC02733, PDE4D, and TRIM14, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, CAMP catabolic process activity versus LINC02733 in GBM (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LINC02733 →	-0.285	-0.703	<.001	<.001	3	5
LUAD	PDE4D →	+0.921	+0.313	<.001	.001	3	4
LUAD	TRIM14 →	-0.506	-0.357	<.001	.009	3	3
LSCC	ZNF185 →	-0.745	-0.145	.007	.009	3	3
LUAD	SNX2P2 →	+0.637	+0.355	<.001	.003	3	3
LUAD	NDUFB4P2 →	+1.107	+0.326	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006198 vs LINC02733 — GBM

Explore this scatter interactively →