AMP catabolic process

Across TCGA patient cohorts, RNA activity of the AMP catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are XDH, RAC2, and LILRA1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, AMP catabolic process activity versus XDH in UCEC (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	XDH →	+1.626	+0.176	<.001	<.001	3	6
LSCC	RAC2 →	+0.508	+0.159	<.001	<.001	3	6
UCEC	LILRA1 →	+0.501	+0.223	.005	<.001	3	5
LSCC	ADGRE2 →	+0.582	+0.250	<.001	<.001	3	5
HNSC	IDO1 →	+1.407	+0.199	.001	<.001	3	5
LSCC	PRAM1 →	+0.413	+0.237	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006196 vs XDH — UCEC

Explore this scatter interactively →