AMP catabolic process

Across TCGA patient cohorts, RNA activity of the AMP catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are XDH, VSIR, and SART3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, AMP catabolic process activity versus XDH in OV (Pearson r = 0.52).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	XDH →	+1.221	+0.206	.001	.002	2	7
UCEC	VSIR →	+0.486	+0.152	.002	.001	3	5
LSCC	SART3 →	-0.262	-0.260	<.001	<.001	3	4
UCEC	ACTR2 →	+0.175	+0.207	<.001	<.001	3	4
HNSC	DYSF →	+0.611	+0.141	.001	.003	2	5
LSCC	GMIP →	+0.335	+0.251	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006196 vs XDH — OV

Explore this scatter interactively →