AMP catabolic process

Across TCGA cell cohorts, RNA activity of the AMP catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP6V1B2, CALHM5, and KAT8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATP6V1B2 grouped by AMP catabolic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ATP6V1B2 →	+0.630	+1.407	.005	.003	3	4
LUNG_SCLC	CALHM5 →	-0.248	-1.480	.002	.001	3	4
BREAST	KAT8 →	+0.275	+1.109	<.001	.002	3	4
LUNG_SCLC	KLF6 →	-0.373	-1.352	<.001	.003	3	3
BREAST	TBCE →	+0.504	+1.217	<.001	<.001	3	3
BREAST	CDK13 →	-0.172	-0.709	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATP6V1B2 by AMP catabolic process activity — LUNG_SCLC

Explore this box plot interactively →