AMP catabolic process

Across TCGA cell cohorts, RNA activity of the AMP catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NT5E, MAGEF1, and ADA, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, AMP catabolic process activity versus NT5E in LUNG_NSCLC_LUSC (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	NT5E →	+5.022	+1.122	<.001	.001	3	14
LUNG_NSCLC_LUSC	MAGEF1 →	-1.335	-0.810	<.001	.001	3	10
LUNG_SCLC	ADA →	+2.472	+1.704	<.001	<.001	3	10
LUNG_NSCLC_LUSC	CBX2 →	-1.536	-0.784	.001	.002	3	9
BREAST	FOSL1 →	+3.528	+1.296	<.001	<.001	3	9
BREAST	SPRYD4 →	-0.584	-1.040	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006196 vs NT5E — LUNG_NSCLC_LUSC

Explore this scatter interactively →