IMP biosynthetic process

Across TCGA patient cohorts, RNA activity of the IMP biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TBL3, UTP15, and UTP4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, IMP biosynthetic process activity versus TBL3 in PDAC (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TBL3 →	+0.220	+0.044	<.001	<.001	3	6
UCEC	UTP15 →	+0.344	+0.065	<.001	<.001	3	6
UCEC	UTP4 →	+0.357	+0.060	<.001	<.001	3	6
UCEC	WDR36 →	+0.242	+0.053	<.001	<.001	3	6
UCEC	WDR43 →	+0.393	+0.056	<.001	<.001	3	6
UCEC	WDR75 →	+0.354	+0.056	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006188 vs TBL3 — PDAC

Explore this scatter interactively →