IMP biosynthetic process

Across TCGA patient cohorts, RNA activity of the IMP biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FCGR2B, LCP2, and LINC02084, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, IMP biosynthetic process activity versus FCGR2B in GBM (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FCGR2B →	+0.742	+0.113	.004	.001	3	6
HNSC	LCP2 →	+0.676	+0.171	.003	<.001	3	5
GBM	LINC02084 →	+0.232	+0.112	.007	<.001	3	5
GBM	SELL →	+1.031	+0.106	<.001	.001	3	5
UCEC	PIK3CG →	+0.489	+0.091	.001	.002	3	4
GBM	FCGR2A →	+0.705	+0.097	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006188 vs FCGR2B — GBM

Explore this scatter interactively →