IMP biosynthetic process

Across TCGA cell cohorts, RNA activity of the IMP biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAPK13, MAP7, and ESRP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAPK13 grouped by IMP biosynthetic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MAPK13 →	+2.835	+1.322	<.001	<.001	3	6
STOMACH	MAP7 →	+2.466	+0.532	<.001	.006	3	5
BREAST	ESRP1 →	+2.851	+0.629	.003	.008	2	6
OVARY	BICDL2 →	+2.120	+0.931	<.001	.002	3	4
OESOPHAGUS	ICA1 →	+2.520	+0.231	<.001	.002	3	4
SOFT_TISSUE	CMIP →	+0.857	+1.071	.006	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAPK13 by IMP biosynthetic process activity — OVARY

Explore this box plot interactively →