IMP biosynthetic process

Across TCGA cell cohorts, RNA activity of the IMP biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THOP1, C1QBP, and ANKRD13B, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, IMP biosynthetic process activity versus THOP1 in STOMACH (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	THOP1 →	+1.095	+0.684	.001	<.001	3	7
KIDNEY	C1QBP →	+0.851	+0.408	.002	.002	3	7
STOMACH	ANKRD13B →	+1.392	+0.466	.008	.001	3	7
LIVER	METAP2 →	+0.737	+0.374	.003	.009	2	8
BREAST	PSME3 →	+0.606	+0.309	.002	.008	3	6
BREAST	RPL13 →	+0.556	+0.305	.004	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006188 vs THOP1 — STOMACH

Explore this scatter interactively →