IMP biosynthetic process

Across TCGA cell cohorts, RNA activity of the IMP biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PAICS, CCT2, and GLOD4, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, IMP biosynthetic process activity versus PAICS in LARGE_INTESTINE (Pearson r = 0.73).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PAICS →	+2.264	+0.859	<.001	.002	3	19
OVARY	CCT2 →	+1.993	+1.366	<.001	<.001	3	19
LARGE_INTESTINE	GLOD4 →	+2.180	+0.601	<.001	.005	3	19
URINARY_TRACT	EIF4H →	+2.472	+1.677	<.001	<.001	3	18
URINARY_TRACT	YWHAE →	+2.163	+1.685	<.001	.003	3	18
URINARY_TRACT	HSPA8 →	+1.194	+1.677	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006188 vs PAICS — LARGE_INTESTINE

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