GTP biosynthetic process

Across TCGA patient cohorts, RNA activity of the GTP biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IFT52, EFHC1, and JPT2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, GTP biosynthetic process activity versus IFT52 in UCEC (Pearson r = 0.55).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IFT52 →	+0.381	+0.090	<.001	<.001	3	6
UCEC	EFHC1 →	+0.622	+0.107	<.001	<.001	3	5
LUAD	JPT2 →	+0.174	+0.032	.004	.008	3	5
LSCC	NME7 →	+0.317	+0.052	<.001	<.001	3	5
UCEC	DYNC2LI1 →	+0.390	+0.068	<.001	<.001	3	5
UCEC	ARL6 →	+0.273	+0.073	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006183 vs IFT52 — UCEC

Explore this scatter interactively →