GTP biosynthetic process

Across TCGA patient cohorts, RNA activity of the GTP biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRRC71, C1orf194, and C6orf118, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, GTP biosynthetic process activity versus LRRC71 in LSCC (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LRRC71 →	+0.490	+0.209	<.001	.001	3	5
LSCC	C1orf194 →	+0.607	+0.200	<.001	.001	3	5
UCEC	C6orf118 →	+1.365	+0.212	.004	.002	3	4
UCEC	CAPSL →	+1.205	+0.143	.003	.003	3	4
LUAD	DYNLRB2 →	+0.601	+0.181	.003	.001	3	4
LUAD	MORN5 →	+0.883	+0.217	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006183 vs LRRC71 — LSCC

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