GTP biosynthetic process

Across TCGA cell cohorts, RNA activity of the GTP biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NME1, NME2, and PAM16, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, GTP biosynthetic process activity versus NME1 in LUNG_NSCLC_LUAD (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	NME1 →	+0.670	+0.225	<.001	.005	3	8
LUNG_SCLC	NME2 →	+1.028	+0.331	.003	.001	2	7
LUNG_SCLC	PAM16 →	+0.964	+0.472	<.001	<.001	3	6
KIDNEY	ARF1 →	+0.753	+0.330	.006	.003	3	5
KIDNEY	CCT8 →	+0.791	+0.369	.005	.004	3	5
STOMACH	NPM3 →	+1.092	+0.526	.003	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006183 vs NME1 — LUNG_NSCLC_LUAD

Explore this scatter interactively →