GTP biosynthetic process

Across TCGA cell cohorts, RNA activity of the GTP biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NACA, NME2, and PFDN2, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, GTP biosynthetic process activity versus NACA in STOMACH (Pearson r = 0.85).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	NACA →	+2.567	+0.755	<.001	.003	3	18
UPPER_AERODIGESTIVE_TRACT	NME2 →	+1.345	+0.678	<.001	<.001	3	18
LUNG_NSCLC_LUSC	PFDN2 →	+2.495	+0.531	<.001	<.001	3	18
STOMACH	UBE2N →	+1.951	+0.860	<.001	.008	3	17
LUNG_NSCLC_LUSC	NME1 →	+1.965	+0.633	<.001	<.001	2	18
UPPER_AERODIGESTIVE_TRACT	HSP90AB1 →	+1.588	+0.652	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006183 vs NACA — STOMACH

Explore this scatter interactively →