CGMP biosynthetic process

Across TCGA patient cohorts, RNA activity of the CGMP biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GUCY1A1, GUCY1B1, and TNS2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, CGMP biosynthetic process activity versus GUCY1A1 in OV (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GUCY1A1 →	+0.548	+0.082	<.001	<.001	3	9
OV	GUCY1B1 →	+0.611	+0.097	<.001	<.001	3	9
CCRCC	TNS2 →	+0.448	+0.110	<.001	<.001	3	8
GBM	COL14A1 →	+0.997	+0.120	<.001	<.001	3	8
GBM	CYGB →	+0.419	+0.076	<.001	<.001	3	8
CCRCC	CDH5 →	+0.497	+0.099	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006182 vs GUCY1A1 — OV

Explore this scatter interactively →