CGMP biosynthetic process

Across TCGA patient cohorts, RNA activity of the CGMP biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCM4, LAMA2, and PKM, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, CGMP biosynthetic process activity versus MCM4 in COAD (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MCM4 →	-0.737	-0.170	<.001	<.001	3	5
LSCC	LAMA2 →	+0.723	+0.623	.001	.005	3	4
COAD	PKM →	-0.828	-0.243	<.001	.003	3	4
BRCA	RASGRP2 →	+0.586	+0.609	<.001	<.001	3	4
COAD	CDCA5 →	-0.813	-0.156	<.001	.001	3	4
COAD	FAM86C1P →	-0.269	-0.155	.002	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006182 vs MCM4 — COAD

Explore this scatter interactively →