GMP biosynthetic process

Across TCGA patient cohorts, RNA activity of the GMP biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEH1L, ADA, and AUNIP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, GMP biosynthetic process activity versus SEH1L in LSCC (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SEH1L →	+0.371	+0.081	.001	.003	3	6
COAD	ADA →	+0.677	+0.138	<.001	.004	2	6
UCEC	AUNIP →	+0.681	+0.140	<.001	<.001	3	5
LUAD	CENPE →	+0.758	+0.146	<.001	<.001	3	5
LSCC	PARPBP →	+0.756	+0.152	<.001	<.001	3	5
LUAD	DEPDC1 →	+0.821	+0.117	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006177 vs SEH1L — LSCC

Explore this scatter interactively →