ADP biosynthetic process

Across TCGA patient cohorts, RNA activity of the ADP biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AK4, FKBP7, and ZEB2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ADP biosynthetic process activity versus AK4 in UCEC (Pearson r = 0.70).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AK4 →	+0.765	+0.161	<.001	<.001	3	9
OV	FKBP7 →	-0.574	-0.070	.003	.006	3	6
PDAC	ZEB2 →	-0.210	-0.067	.002	.006	3	6
HNSC	MACF1_S4521 →	+0.423	+0.070	.005	.006	3	6
UCEC	HABP4 →	-0.371	-0.136	<.001	<.001	3	6
LSCC	CA9 →	+0.788	+0.064	.003	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006172 vs AK4 — UCEC

Explore this scatter interactively →