ADP biosynthetic process

Across TCGA patient cohorts, RNA activity of the ADP biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AK4, ASPHD1, and AK4P1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ADP biosynthetic process activity versus AK4 in COAD (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	AK4 →	+1.409	+0.195	<.001	<.001	3	7
COAD	ASPHD1 →	+0.615	+0.109	<.001	.002	3	4
COAD	AK4P1 →	+0.667	+0.148	<.001	<.001	3	4
LSCC	GFOD2 →	+0.326	+0.121	.003	<.001	3	4
LSCC	LRRC75B →	+0.452	+0.127	.007	.001	3	4
GBM	PALM →	+0.951	+0.177	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006172 vs AK4 — COAD

Explore this scatter interactively →