ADP biosynthetic process

Across TCGA cell cohorts, RNA activity of the ADP biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APEH, WWC2, and ERGIC2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, APEH grouped by ADP biosynthetic process-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	APEH →	-0.743	-1.418	.007	.004	3	4
LARGE_INTESTINE	WWC2 →	-2.781	-1.336	<.001	<.001	3	4
LIVER	ERGIC2 →	-0.763	-1.476	.003	.001	3	4
SKIN	ACTR3B →	+0.669	+1.140	.004	<.001	3	4
LIVER	PREX1 →	-2.373	-1.526	.002	.001	3	4
LIVER	AFMID →	+1.536	+1.424	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

APEH by ADP biosynthetic process activity — URINARY_TRACT

Explore this box plot interactively →