ADP biosynthetic process

Across TCGA cell cohorts, RNA activity of the ADP biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AK4, AK1, and THSD1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ADP biosynthetic process activity versus AK4 in BLOOD_Lymphoma (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	AK4 →	+2.959	+0.345	<.001	<.001	3	9
BLOOD_Lymphoma	AK1 →	+1.975	+0.268	.001	.002	3	5
BLOOD_Lymphoma	THSD1 →	+1.266	+0.366	.006	<.001	3	5
BLOOD_Lymphoma	IL32 →	+5.071	+0.264	<.001	.003	3	4
SOFT_TISSUE	PHACTR2 →	+1.536	+0.283	.004	.003	3	4
SOFT_TISSUE	THAP12 →	+0.667	+0.274	.003	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006172 vs AK4 — BLOOD_Lymphoma

Explore this scatter interactively →