CAMP biosynthetic process

Across TCGA patient cohorts, RNA activity of the CAMP biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SPARCL1_S295, BGN, and KANK2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, CAMP biosynthetic process activity versus SPARCL1_S295 in BRCA (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SPARCL1_S295 →	+0.767	+0.045	.001	.002	3	7
CCRCC	BGN →	+0.677	+0.045	<.001	.008	3	6
UCEC	KANK2 →	+0.503	+0.053	<.001	.002	3	6
OV	LUM →	+0.621	+0.045	.001	.007	3	6
BRCA	ITGA7 →	+0.964	+0.072	<.001	<.001	3	6
PDAC	REEP4_S152 →	-0.649	-0.052	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006171 vs SPARCL1_S295 — BRCA

Explore this scatter interactively →