CAMP biosynthetic process

Across TCGA patient cohorts, RNA activity of the CAMP biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PUDP, CENPW, and DNMT1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, CAMP biosynthetic process activity versus PUDP in HNSC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PUDP →	+0.464	+0.267	.001	<.001	3	5
GBM	CENPW →	-0.672	-0.762	.003	<.001	3	5
GBM	DNMT1 →	-0.548	-0.661	<.001	.001	3	4
PDAC	PODNL1 →	-0.555	-0.340	<.001	<.001	3	4
CCRCC	SNORD11 →	-0.375	-0.183	.006	.009	3	4
PDAC	RBM28 →	-0.248	-0.307	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006171 vs PUDP — HNSC

Explore this scatter interactively →