CAMP biosynthetic process

Across TCGA cell cohorts, RNA activity of the CAMP biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CORO7, SLC12A6, and EFCAB6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CORO7 grouped by CAMP biosynthetic process-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CORO7 →	+0.949	+0.323	.006	<.001	3	5
URINARY_TRACT	SLC12A6 →	+1.476	+0.323	<.001	<.001	3	4
URINARY_TRACT	EFCAB6 →	+0.496	+0.322	<.001	<.001	3	4
STOMACH	NDUFA6 →	+0.556	+0.243	.004	.002	3	3
STOMACH	ZNF836 →	-1.721	-0.302	.005	.004	3	3
STOMACH	ZNF607 →	-1.240	-0.284	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CORO7 by CAMP biosynthetic process activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →