AMP biosynthetic process

Across TCGA patient cohorts, RNA activity of the AMP biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADSS1, LRRN4, and SLC34A2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, AMP biosynthetic process activity versus ADSS1 in PDAC (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ADSS1 →	+0.669	+0.160	<.001	<.001	3	6
LUAD	LRRN4 →	-1.047	-0.118	.002	.002	3	4
CCRCC	SLC34A2 →	-2.323	-0.182	<.001	.001	3	4
GBM	PTPN3 →	-0.732	-0.080	.005	.006	3	4
OV	SLC6A20 →	-0.892	-0.160	.006	.001	3	4
BRCA	CLEC10A →	+0.839	+0.093	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006167 vs ADSS1 — PDAC

Explore this scatter interactively →