Purine ribonucleoside salvage

Across TCGA cell cohorts, RNA activity of the Purine ribonucleoside salvage pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APRT, MTAP, and PRTFDC1, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, APRT grouped by Purine ribonucleoside salvage-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	APRT →	-0.330	-1.218	<.001	.001	3	14
SOFT_TISSUE	MTAP →	-0.192	-1.070	.003	.008	3	6
SKIN	PRTFDC1 →	-0.221	-0.728	<.001	.009	3	6
OVARY	PGM2 →	-0.294	-1.322	<.001	<.001	3	5
BREAST	PNP →	-0.101	-0.747	.003	.005	2	6
SKIN	IKZF2 →	-0.123	-0.786	.009	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

APRT by Purine ribonucleoside salvage activity — OVARY

Explore this box plot interactively →