Purine ribonucleoside salvage

Across TCGA cell cohorts, RNA activity of the Purine ribonucleoside salvage pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHD4, SRSF9, and MMACHC, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine ribonucleoside salvage activity versus CHD4 in PANCREAS (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CHD4 →	+0.497	+1.389	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	SRSF9 →	+1.145	+1.979	<.001	<.001	3	6
PANCREAS	MMACHC →	+0.901	+1.329	<.001	<.001	3	5
PANCREAS	UBP1 →	+0.820	+1.469	.003	<.001	3	5
LIVER	HPRT1 →	+1.394	+1.678	.003	.001	3	5
PANCREAS	APEX1 →	+0.887	+1.102	.004	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006166 vs CHD4 — PANCREAS

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