Purine nucleoside catabolic process

Across TCGA patient cohorts, RNA activity of the Purine nucleoside catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are XDH, CYTH4, and CD40, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleoside catabolic process activity versus XDH in UCEC (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	XDH →	+1.429	+0.190	.004	.003	3	6
HNSC	CYTH4 →	+0.657	+0.114	.005	.001	3	6
UCEC	CD40 →	+0.708	+0.175	<.001	<.001	3	5
UCEC	IL2RA →	+0.933	+0.214	.002	.009	3	5
LUAD	MLKL →	+0.481	+0.145	.001	.006	3	5
UCEC	PTAFR →	+1.271	+0.275	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006152 vs XDH — UCEC

Explore this scatter interactively →