Purine nucleobase metabolic process

Across TCGA patient cohorts, RNA activity of the Purine nucleobase metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MCM6_S762, CMSS1, and MCM5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleobase metabolic process activity versus MCM6_S762 in LUAD (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MCM6_S762 →	+0.958	+0.044	.001	<.001	3	7
BRCA	CMSS1 →	+0.511	+0.045	<.001	<.001	3	6
BRCA	MCM5 →	+0.671	+0.056	<.001	<.001	3	6
HNSC	MSH6 →	+0.600	+0.102	<.001	<.001	3	6
BRCA	SPC24 →	+0.499	+0.045	<.001	.001	3	6
COAD	SHMT1 →	+0.484	+0.043	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006144 vs MCM6_S762 — LUAD

Explore this scatter interactively →