Purine nucleobase metabolic process

Across TCGA cell cohorts, RNA activity of the Purine nucleobase metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MGAT1, C15orf62, and ARPP19, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MGAT1 grouped by Purine nucleobase metabolic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MGAT1 →	-0.844	-1.246	.004	.004	3	6
BREAST	C15orf62 →	+0.754	+0.973	.004	.003	3	5
LIVER	ARPP19 →	+0.619	+1.533	.004	.004	3	5
KIDNEY	CHRNA5 →	+1.003	+1.236	.008	.002	3	5
BREAST	EHD2 →	-1.571	-0.773	.004	.001	3	4
LIVER	USP3 →	+1.119	+1.469	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MGAT1 by Purine nucleobase metabolic process activity — STOMACH

Explore this box plot interactively →