Purine nucleobase metabolic process

Across TCGA cell cohorts, RNA activity of the Purine nucleobase metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SHMT1, COPS3, and SUV39H2, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleobase metabolic process activity versus SHMT1 in PANCREAS (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SHMT1 →	+1.183	+0.157	<.001	<.001	3	15
BREAST	COPS3 →	+0.882	+0.124	.002	<.001	3	14
BLOOD_Myeloma	SUV39H2 →	+1.084	+0.100	.001	<.001	3	14
OESOPHAGUS	PPAT →	+1.109	+0.161	.004	.002	3	13
STOMACH	NAE1 →	+0.758	+0.114	.002	.001	3	13
BLOOD_Myeloma	PGAM1 →	+0.780	+0.079	.008	.009	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006144 vs SHMT1 — PANCREAS

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