Purine nucleobase metabolic process

Across TCGA cell cohorts, RNA activity of the Purine nucleobase metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPL30, ANKRD13B, and CLPP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleobase metabolic process activity versus MRPL30 in PANCREAS (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MRPL30 →	+0.650	+0.494	<.001	.003	3	7
STOMACH	ANKRD13B →	+2.593	+0.460	<.001	.001	3	6
PANCREAS	CLPP →	+1.014	+0.466	<.001	<.001	3	6
STOMACH	KLF16 →	+1.534	+0.434	<.001	<.001	3	6
STOMACH	EEF2 →	+1.158	+0.374	.005	.001	3	6
BLOOD_Leukemia	PPAT →	+0.806	+0.209	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006144 vs MRPL30 — PANCREAS

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