Regulation of nucleotide metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of nucleotide metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are YTHDC1, FBXO2, and TMF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of nucleotide metabolic process activity versus YTHDC1 in OV (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	YTHDC1 →	-0.268	-0.028	.003	.001	3	5
LSCC	FBXO2 →	+0.697	+0.035	<.001	<.001	3	4
BRCA	TMF1 →	-0.236	-0.015	.002	.009	3	4
LSCC	TRIR →	-0.245	-0.030	.002	.003	3	4
GBM	CCAR1 →	-0.211	-0.047	.001	<.001	3	4
CCRCC	EPHB2 →	+0.470	+0.068	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006140 vs YTHDC1 — OV

Explore this scatter interactively →