Regulation of nucleotide metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of nucleotide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIM13, CLCC1, and H2BC21, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of nucleotide metabolic process activity versus TRIM13 in GBM (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TRIM13 →	-0.568	-0.125	<.001	.003	3	4
PDAC	CLCC1 →	-0.262	-0.155	<.001	<.001	3	4
BRCA	H2BC21 →	-0.834	-0.143	.007	.005	3	4
BRCA	RAD51D →	-0.270	-0.115	.002	.004	3	4
CCRCC	SEPTIN7P13 →	-0.320	-0.109	.001	.006	3	4
PDAC	GPR141 →	-0.337	-0.085	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006140 vs TRIM13 — GBM

Explore this scatter interactively →