Regulation of nucleotide metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of nucleotide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPL2, GON4L, and DCTN3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MRPL2 grouped by Regulation of nucleotide metabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MRPL2 →	+0.677	+0.153	.003	.006	3	4
BLOOD_Leukemia	GON4L →	+0.343	+0.135	.007	.004	3	4
UPPER_AERODIGESTIVE_TRACT	DCTN3 →	-1.126	-0.252	.004	.003	3	4
OVARY	RAB3B →	-1.709	-0.194	.002	.005	3	4
OVARY	TNFRSF6B →	-2.448	-0.190	.004	<.001	3	4
URINARY_TRACT	KLHDC3 →	+1.130	+0.298	.009	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MRPL2 by Regulation of nucleotide metabolic process activity — BREAST

Explore this box plot interactively →