Regulation of nucleotide metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of nucleotide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAMTOR4, FAM221A, and LMNA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of nucleotide metabolic process activity versus LAMTOR4 in BLOOD_Lymphoma (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	LAMTOR4 →	+0.738	+0.202	.006	.001	3	6
BLOOD_Lymphoma	FAM221A →	+1.574	+0.137	.001	.008	3	6
BLOOD_Lymphoma	LMNA →	-4.233	-0.205	<.001	.001	3	5
BLOOD_Lymphoma	PNKD →	+0.947	+0.218	.003	.006	3	5
BLOOD_Lymphoma	CEMIP2 →	-2.089	-0.202	<.001	<.001	3	5
BLOOD_Lymphoma	MAP3K4 →	-1.319	-0.250	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006140 vs LAMTOR4 — BLOOD_Lymphoma

Explore this scatter interactively →