"Mitochondrial electron transport, cytochrome c to oxygen"

Across TCGA patient cohorts, RNA activity of the "Mitochondrial electron transport, cytochrome c to oxygen" pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EIF3A, LTBP4, and P4HB, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Mitochondrial electron transport, cytochrome c to oxygen" activity versus EIF3A in COAD (Pearson r = -0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	EIF3A →	-0.146	-0.026	.001	.002	3	6
BRCA	LTBP4 →	+0.511	+0.038	<.001	<.001	3	6
CCRCC	P4HB →	-0.355	-0.032	<.001	<.001	3	6
GBM	CNRIP1 →	+0.649	+0.066	<.001	<.001	3	5
BRCA	ADD1 →	+0.271	+0.027	.005	.008	3	5
LUAD	SLC4A7_S242 →	-0.665	-0.037	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006123 vs EIF3A — COAD

Explore this scatter interactively →