"Mitochondrial electron transport, cytochrome c to oxygen"

Across TCGA cell cohorts, RNA activity of the "Mitochondrial electron transport, cytochrome c to oxygen" pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITPR2, XYLT2, and ZNF525, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ITPR2 grouped by "Mitochondrial electron transport, cytochrome c to oxygen"-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ITPR2 →	+1.001	+0.934	.004	.004	3	4
BREAST	XYLT2 →	+1.063	+0.794	<.001	.001	3	4
BREAST	ZNF525 →	+1.027	+0.712	.002	.003	3	4
BREAST	ETV1 →	-1.365	-0.553	.001	.003	3	4
BLOOD_Leukemia	TEPSIN →	+0.590	+1.274	.004	.006	3	3
BLOOD_Leukemia	TSEN54 →	+1.128	+1.446	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ITPR2 by "Mitochondrial electron transport, cytochrome c to oxygen" activity — BLOOD_Leukemia

Explore this box plot interactively →