"Mitochondrial electron transport, cytochrome c to oxygen"

Across TCGA cell cohorts, RNA activity of the "Mitochondrial electron transport, cytochrome c to oxygen" pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PFDN4, NAT10, and DAZAP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Mitochondrial electron transport, cytochrome c to oxygen" activity versus PFDN4 in URINARY_TRACT (Pearson r = -0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PFDN4 →	-0.611	-0.161	.002	<.001	3	6
PANCREAS	NAT10 →	-1.108	-0.139	<.001	<.001	3	6
LUNG_NSCLC_LUAD	DAZAP1 →	-0.363	-0.104	<.001	<.001	3	5
LUNG_SCLC	BLMH →	-0.871	-0.108	<.001	.009	3	5
BLOOD_Lymphoma	TXLNA →	+0.905	+0.194	<.001	.001	3	4
STOMACH	GCC2 →	+1.359	+0.161	.007	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006123 vs PFDN4 — URINARY_TRACT

Explore this scatter interactively →