"Mitochondrial electron transport, succinate to ubiquinone"

Across TCGA patient cohorts, RNA activity of the "Mitochondrial electron transport, succinate to ubiquinone" pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SUB1, SDHAF2, and CCDC127, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Mitochondrial electron transport, succinate to ubiquinone" activity versus SUB1 in UCEC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SUB1 →	+0.418	+0.062	<.001	<.001	3	6
LUAD	SDHAF2 →	+1.010	+0.066	<.001	<.001	3	5
HNSC	CCDC127 →	+0.354	+0.058	<.001	<.001	3	5
HNSC	MTMR12 →	+0.251	+0.055	<.001	<.001	3	5
LSCC	PDCD6 →	+0.257	+0.050	<.001	<.001	3	5
PDAC	TCEA3 →	+0.361	+0.025	.001	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006121 vs SUB1 — UCEC

Explore this scatter interactively →