"Mitochondrial electron transport, succinate to ubiquinone"

Across TCGA patient cohorts, RNA activity of the "Mitochondrial electron transport, succinate to ubiquinone" pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFRSF4, CSF2RB, and TNFRSF8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Mitochondrial electron transport, succinate to ubiquinone" activity versus TNFRSF4 in OV (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TNFRSF4 →	-0.580	-0.126	.003	.003	3	4
COAD	CSF2RB →	-0.697	-0.146	.003	.005	3	4
COAD	TNFRSF8 →	-0.239	-0.139	<.001	<.001	3	4
COAD	TTC24 →	-0.278	-0.187	.001	<.001	3	4
COAD	PRR33 →	-0.466	-0.147	<.001	.007	3	4
OV	RETN →	-0.777	-0.125	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006121 vs TNFRSF4 — OV

Explore this scatter interactively →