"Mitochondrial electron transport, succinate to ubiquinone"

Across TCGA cell cohorts, RNA activity of the "Mitochondrial electron transport, succinate to ubiquinone" pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADA, HSD11B1L, and RBP7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Mitochondrial electron transport, succinate to ubiquinone" activity versus ADA in OESOPHAGUS (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ADA →	+1.406	+0.173	.003	.004	3	4
BREAST	HSD11B1L →	+1.469	+0.145	.009	<.001	3	4
OESOPHAGUS	RBP7 →	+2.138	+0.121	.004	.008	3	4
OESOPHAGUS	RAB42 →	+1.516	+0.119	.006	.008	3	3
OESOPHAGUS	PNPLA6 →	+1.165	+0.145	.004	.001	3	3
PANCREAS	SMARCD3 →	+1.921	+0.129	.007	.007	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006121 vs ADA — OESOPHAGUS

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