"Mitochondrial electron transport, NADH to ubiquinone"

Across TCGA patient cohorts, RNA activity of the "Mitochondrial electron transport, NADH to ubiquinone" pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COQ9, MAPK6_S189, and COQ8A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Mitochondrial electron transport, NADH to ubiquinone" activity versus COQ9 in COAD (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	COQ9 →	+0.448	+0.023	<.001	.002	3	6
CCRCC	MAPK6_S189 →	-0.544	-0.043	.004	.001	3	5
UCEC	COQ8A →	+0.408	+0.060	.003	.002	3	5
GBM	UQCR10 →	+0.522	+0.070	<.001	<.001	3	5
GBM	MMP14 →	-0.629	-0.054	<.001	<.001	3	5
GBM	NAXE →	+0.237	+0.054	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006120 vs COQ9 — COAD

Explore this scatter interactively →