"Mitochondrial electron transport, NADH to ubiquinone"

Across TCGA patient cohorts, RNA activity of the "Mitochondrial electron transport, NADH to ubiquinone" pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIRREL1, TMSB10, and CAV2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Mitochondrial electron transport, NADH to ubiquinone" activity versus KIRREL1 in GBM (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	KIRREL1 →	-0.691	-0.119	.002	<.001	3	5
LSCC	TMSB10 →	-0.588	-0.275	<.001	<.001	3	5
BRCA	CAV2 →	-0.838	-0.126	<.001	.007	3	4
BRCA	PXDN →	-1.041	-0.187	<.001	<.001	3	4
LSCC	GPX8 →	-0.859	-0.202	<.001	.001	3	4
GBM	CAV1 →	-1.240	-0.096	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006120 vs KIRREL1 — GBM

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