"Mitochondrial electron transport, NADH to ubiquinone"

Across TCGA cell cohorts, RNA activity of the "Mitochondrial electron transport, NADH to ubiquinone" pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEACAM5, IGFBP4, and HID1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CEACAM5 grouped by "Mitochondrial electron transport, NADH to ubiquinone"-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CEACAM5 →	+2.711	+0.326	<.001	.003	3	4
LUNG_SCLC	IGFBP4 →	-2.509	-0.256	.004	.006	3	4
BREAST	HID1 →	+2.539	+0.283	<.001	<.001	3	4
BREAST	CIPC →	+0.685	+0.345	.004	.001	3	4
BREAST	SLC16A3 →	-2.375	-0.320	.002	<.001	3	3
BREAST	INPP1 →	-1.338	-0.289	.006	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CEACAM5 by "Mitochondrial electron transport, NADH to ubiquinone" activity — BREAST

Explore this box plot interactively →