Oxidative phosphorylation

Across TCGA patient cohorts, RNA activity of the Oxidative phosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the KIRP cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL9P29, LINC01970, and RPS23P6, each associated with the pathway in up to 28 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oxidative phosphorylation activity versus RPL9P29 in KIRP (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRP	RPL9P29 →	+0.960	+0.030	<.001	<.001	3	28
TGCT	LINC01970 →	+0.303	+0.027	<.001	<.001	3	27
KIRP	RPS23P6 →	+1.002	+0.034	<.001	<.001	3	26
KIRP	PDCL3P4 →	+1.067	+0.031	<.001	<.001	3	26
LAML	FAAHP1 →	+0.751	+0.033	<.001	<.001	3	26
THYM	NDUFA2 →	+0.584	+0.022	<.001	<.001	3	25

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006119 vs RPL9P29 — KIRP

Explore this scatter interactively →