Oxidative phosphorylation

Across TCGA patient cohorts, RNA activity of the Oxidative phosphorylation pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TFB2M, VPS13C_S737, and ANXA2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oxidative phosphorylation activity versus TFB2M in LUAD (Pearson r = 0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TFB2M →	+0.531	+0.033	<.001	<.001	3	6
LSCC	VPS13C_S737 →	-0.418	-0.033	.003	.001	3	6
HNSC	ANXA2 →	-0.383	-0.069	<.001	.006	3	6
LSCC	AKAP13_S2498 →	-0.445	-0.048	<.001	<.001	3	6
OV	NFU1 →	+0.378	+0.032	.002	.004	3	5
PDAC	FLNB_S2481 →	-0.340	-0.016	.003	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006119 vs TFB2M — LUAD

Explore this scatter interactively →