Oxidative phosphorylation

Across TCGA patient cohorts, RNA activity of the Oxidative phosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIRREL1, SYDE1, and SPRED1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oxidative phosphorylation activity versus KIRREL1 in LUAD (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	KIRREL1 →	-0.720	-0.177	<.001	.002	3	6
CCRCC	SYDE1 →	-0.478	-0.176	.002	.002	3	5
LSCC	SPRED1 →	-0.485	-0.158	.001	.005	3	5
UCEC	FNDC4 →	-0.694	-0.201	<.001	<.001	3	5
UCEC	SEMA7A →	-0.779	-0.325	.001	<.001	3	5
UCEC	CD300A →	-0.765	-0.148	<.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006119 vs KIRREL1 — LUAD

Explore this scatter interactively →