NADH oxidation

pathway activity — cross-omics
GO:0006116Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the NADH oxidation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PCK2, RBM47, and MAP7_S315, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
HNSCPCK2 →+0.460+0.122<.001<.00139
BRCARBM47 →+0.521+0.114<.001<.00137
GBMMAP7_S315 →+0.964+0.113<.001<.00136
CCRCCPLOD1 →-0.534-0.115<.001<.00136
HNSCFGD1_T711 →-0.419-0.106.003.00236
BRCANOS1AP →+0.476+0.077<.001<.00135
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration